What is Anencephaly?
Anencephaly is a defect in the closure of the neural tube during fetal development. The neural tube is a narrow channel that folds and closes between the 3rd and 4th weeks of pregnancy to form the brain and spinal cord of the embryo. Anencephaly occurs when the "cephalic" or head end of the neural tube fails to close, resulting in the absence of a major portion of the brain, skull, and scalp. Infants with this disorder are born without a forebrain (the front part of the brain) and a cerebrum (the thinking and coordinating part of the brain). The remaining brain tissue is often exposed--not covered by bone or skin. A baby born with anencephaly is usually blind, deaf, unconscious, and unable to feel pain. Although some individuals with anencephaly may be born with a rudimentary brain stem, the lack of a functioning cerebrum permanently rules out the possibility of ever gaining consciousness. Reflex actions such as breathing and responses to sound or touch may occur.
An alpha-fetoprotein (AFP) blood test checks the level of AFP in a pregnant woman's blood. AFP is a substance made in the liver of a unborn baby (fetus). The amount of AFP in the blood of a pregnant woman can help see whether the baby may have such problems as spina bifida and anencephaly. An AFP test can also be done as part of a screening test to find other chromosomal problems, such as Down syndrome (trisomy 21) or Edward syndrome (trisomy 18). An AFP test can find an omphalocele, a congenital problem in which some of the baby's intestines stick out through the belly wall.
Normally, low levels of AFP can be found in the blood of a pregnant woman. No AFP (or only a very low level) is generally found in the blood of healthy men or healthy, nonpregnant women.
Showing posts with label pregnancy. Show all posts
Showing posts with label pregnancy. Show all posts
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Human Alpha Fetoprotein not AFP Apple Filing Protocol
I know this is a burning question that everyone has on their mind such as where does AFP come from, what is it exactly and I'm not talking about "Apple Filing Protocol" but alpha fetoprotein AFP which is protein used in a number of blood tests for screening.
Lee Biosolutions is a major supplier of tumor markers such as alpha fetoprotein for the clinical diagnostic . We also specialize in the development and purification of cardiac markers , tumor markers , acute phase proteins , coagulation proteins and immunoassay biomarkers .
Now What is AFP exactly? Human AFP , is a major serum protein of 590 amino acids and a carbohydrate moiety that is normally produced by the fetal yolk sac, the fetal gastrointestinal tract, and eventually by the fetal liver. Alpha-fetoprotein (AFP) has a molecular weight of about 69 kDa. According to an article in Tumor Biology there have been at least 4 subfractions expressing different epitopes that were found in native alpha fetoprotein.
Published reports indicate that alpha-fetoprotein (AFP) , expression in adults is often associated with hepatoma or teratoma . The protein is thought to be the fetal counterpart of serum albumin. The alpha-fetoprotein (AFP) , and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. In addition Alpha fetoprotein binds copper, nickel, fatty acids and bilirubin . The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas .
According to WebMDonline an alpha-fetoprotein (AFP) blood test is used to check the level of AFP in a pregnant woman's blood to help see whether the baby may have such problems as spina bifida or anencephaly and chromosomal problems, such as Down syndrome (trisomy 21) or Edward syndrome (trisomy 18).
According to the American Pregnancy association the Triple Test is to determine any potential genetic disorders. The triple test involves testing for Alpha feto protein , Human chorionic gonadotropin (HCG) and unconjugated estriol.
Lee Biosolutions is a major supplier of tumor markers such as alpha fetoprotein for the clinical diagnostic . We also specialize in the development and purification of cardiac markers , tumor markers , acute phase proteins , coagulation proteins and immunoassay biomarkers .
Now What is AFP exactly? Human AFP , is a major serum protein of 590 amino acids and a carbohydrate moiety that is normally produced by the fetal yolk sac, the fetal gastrointestinal tract, and eventually by the fetal liver. Alpha-fetoprotein (AFP) has a molecular weight of about 69 kDa. According to an article in Tumor Biology there have been at least 4 subfractions expressing different epitopes that were found in native alpha fetoprotein.
Published reports indicate that alpha-fetoprotein (AFP) , expression in adults is often associated with hepatoma or teratoma . The protein is thought to be the fetal counterpart of serum albumin. The alpha-fetoprotein (AFP) , and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. In addition Alpha fetoprotein binds copper, nickel, fatty acids and bilirubin . The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas .
According to WebMDonline an alpha-fetoprotein (AFP) blood test is used to check the level of AFP in a pregnant woman's blood to help see whether the baby may have such problems as spina bifida or anencephaly and chromosomal problems, such as Down syndrome (trisomy 21) or Edward syndrome (trisomy 18).
According to the American Pregnancy association the Triple Test is to determine any potential genetic disorders. The triple test involves testing for Alpha feto protein , Human chorionic gonadotropin (HCG) and unconjugated estriol.
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